ABSTRACT
The aim of this study Observational study is to find out whether thyroid antibodies may serve as an additional independent marker for unexplained recurrent pregnancy loss irrespective of endocrine thyroid function. This study was carried in Tanta University Hospital on 60 pregnant women in the first 20 weeks of gestation. They were divided into three groups: the control group [Group I] included 20 euthyroid pregnant women, the second group [Group II] included 20 euthyroid women who were primary aborters and the third group [Group III] included 20 euthyroid women who were secondary aborters. Laboratory evaluation of serum T3, T4 and TSH was performed for each case. Anti thyroid antibodies [antithyroglobulin antibodies and antimicrosomal antibodies] levels were determined by ELISA test. serum antithyroglobulin and antimicrosomal antibodies levels were significantly elevated in the study groups compared with the control group. Serum antibodies levels were significantly elevated in group III [secondary aborters] compared with group II [primary aborters]. A highly significant association was observed between antibody positivity and missed abortion. Thyroid antibodies are associated with an increased risk of recurrent pregnancy loss and they may be an effective marker of miscarriage risk. Further studies including a larger number of women are needed to confirm the results of the current study